Role of Early Fasciotomy and Skin Cover in the Management of Acute Electrical Burns of the Upper Limbs - A Prospective Case Series

Background: Electrical burn injuries are still amongst the highest accident-related morbidities. Aim: To assess the demographic profile as well as to study outcomes of early fasciotomy in salvage acute electrical burns involving upper limbs. Materials and Methods: The present study was a prospective case series study conducted in Department of Plastic and Reconstructive Surgery at Gandhi Medical College and Hospital, Secunderabad, from January 2020 to January 2022. Total 20 study subjects were evaluated. Electrical burn injury was assessed at the time of admission. Data was analyzed by using coGuide software, V.1.01. Results: In the study population, 55% belonged to age group of 30 years. Male predominance with 75% compared to female. Accidents 40% were major cause of injury. In majority, 65% of the cases fasciotomies were done within 48 hrs of electrical burn injuries. Conclusion: The results of the study concluded that younger generation is more prone to electrical burn injuries and males were majorly affected. Unsafe work areas and accidents are main reasons for injuries. High voltage affected the study population compared to low voltage. Amputations were required in fingers and below elbow. Early fasciotomy, repeated debridement's, definitive skin cover (SSG/flap) have helped in reducing the morbidity and improving the quality of life of the patient.

Association of Serum 8-isoprostaglandin F2? Levels with Glycemic Control in Type 2 Diabetes Patients with Senile Cataract

Background : Lipid Peroxidation (LPO) plays a major initiative factor of cataractogenesis in both age-related or senile cataract and Diabetic cataract. Recently, 8-isoprostaglandin F2? (8-iso-PGF2?) is a reliable biomarker of in-vivo LPO and used as potential indicator of oxidative stress. However, serum 8-iso-PGF2? concentration and its association with glycemic control (HbA1c) in the pathogenesis of diabetic cataract subjects are still unknown. Objectives : The present study was designed to estimate 8-iso-PGF2? and antioxidant enzymes levels in serum of Type 2 Diabetes Mellitus patients with senile cataract compared to healthy individuals without cataract as control. To assess the magnitude of the association between 8-iso-PGF2? and glycemic status in diabetic cataract. Materials and Methods : 60 Diabetic Senile Cataracts (DSC) and 60 healthy individuals without cataract in the age group between 45-75 years of both genders. 8-iso-PGF2?, Superoxide Dismutase [Cu-Zn] (SOD3) and Catalase (CAT) concentration were estimated in serum by ELISA method. Results : The mean concentration of 8-iso-PGF2? was significantly increased (541.6±142.7 pg/ml, p<0.001) and mean concentration of SOD3 (102.1±32.8 ng/ml, p=0.007) and Catalase (1005±274.5 IU/ml, p<0.001) were significantly decreased in serum of diabetic senile cataract when compared to healthy individuals without cataract (control). A negative correlation between serum 8-iso-PGF2? and SOD3 and positive correlation between serum 8- iso-PGF2? and fasting blood glucose were observed in Diabetic Senile Cataracts. Conclusion : The present findings indicate that increased 8-iso-PGF2? is associated with oxidative stress which plays a significant role in the pathogenesis of cataract in diabetic patients

A prospective study of role of doppler in pregnancy and the perinatal outcome

Background: The development of doppler ultrasonographic technology has provided an opportunity to obtain a qualitative and quantitative assessment of maternal and foetal circulation using a non-invasive method. It has been proved by many studies that doppler has a very important role in screening of high-risk pregnancies. Objective of this study was to evaluate the role of colour doppler study in normal and high-risk pregnancy in relation to perinatal outcome.Methods: A prospective study was done including 75 women with high risk pregnancy and 75 normal pregnant women during the period October 2018 to September 2019 in hospitals attached to Bangalore Medical College and Research Institute. Doppler examination was done after recording patients’ history, clinical examination and ultrasound. Results were analysed and conclusions were made.Results: Out of the 22 patients with PIH, 20 patients had abnormal umbilical artery S/D ratio and all 22 had abnormal MCA PI. Out of 12 patients with diabetes, 10 had abnormal umbilical artery S/D ratio. All the patients with IUGR had abnormal umbilical artery S/D ratio and abnormal MCA PI.Conclusions: Colour doppler flow velocimetry done repeatedly can predict adverse foetal events with a great degree of accuracy.

First and second trimester bleeding and pregnancy outcome: a prospective study in a tertiary government hospital

Background: Bleeding in first and second trimester of pregnancy is one of the common complications of pregnancy. there is evidence from various prospective and retrospective studies that first and second trimester vaginal bleeding which continue with pregnancy is associated with adverse pregnancy outcome, including preterm delivery, low birth weight babies, perinatal death and congenital anomalies. Objective of this study was to know the outcome of pregnancies who have bleeding in first and second trimester of pregnancy.Methods: This study was prospective study done in the department of obstetrics and gynaecology, Vanivilas Hospital, Bangalore from September 2018 to August 2019.Results: This study concludes that I trimester vaginal bleeding are at increased risk of abortion than in II trimester vaginal bleeding. Risk of placenta previa was more in II trimester vaginal bleeding than in I trimester vaginal bleeding.Conclusions: This study concludes that I trimester vaginal bleeding are at increased risk of abortion than in II trimester vaginal bleeding. Risk of placenta previa was more in II trimester vaginal bleeding than in I trimester vaginal bleeding. Bleeding in I trimester and II trimester call for special attention in view of increased risk of preterm birth and perinatal death. Recognition of these association will be useful for detection and follow up of pregnancies being at high risk.

A prospective study of thyroid dysfunction in dysfunctional uterine bleeding

Background: Dysfunctional uterine bleeding is abnormal uterine bleeding in the absence of any palpable pelvic pathology and demonstrable extra genital causes. Thyroid dysfunction is the systemic disease most often associated with abnormal uterine bleeding. Aim was to evaluate thyroid function test in women with DUB; to assess bleeding pattern in thyroid dysfunction.Methods: Prospective observational study was done in the department of obstetrics and gynaecology, Vanivilas hospital, Bangalore from august 2018 to July 2019. Pre structured and predesigned proforma filled. All routine blood investigations including serum T3, T4, TSH, USG were advised. These patients were categorized as euthyroid, subclinical hypothyroid, hypothyroid or hyperthyroid based on thyroid profile.Results: 0.5% belonged to the age group of 31-40 years, prevalence of subclinical hypothyroidism is 11%, there were 5.5% of cases of hypothyroidism and 1.5% case of hyperthyroidism.Conclusions: Thyroid screening must be done mandatory for all the cases of DUB and prompt response to treatment with thyroxine would avoid unnecessary surgeries, hormonal treatment, and associated comorbities.

Retreatment Efficacy of Propoint and Guttapercha - A Cone Beam Computed Tomography Analysis.

Introduction: The present study aimed to evaluate the amount of residual material after retreatment of propoint (DRFP Ltd. Stamford, UK) and gutta-percha obturated using smart paste bio sealer (DRFP Ltd. Stamford, UK), considering gutta-percha and AH Plus (Dentsply Maillefer, Ballaigues, Switzerland) as the standard for comparison. Methods: Forty five single rooted teeth were instrumented using rotary files (F3, Protaper, Dentsply Maillefer, Ballaigues, Switzerland). Obturation was done with three different materials (n=15); group 1, Propoint with smart paste bio, group 2, gutta-percha with smart paste bio and group 3, gutta-percha with AH Plus. Teeth were scanned by cone beam computed tomography to measure the volume of obturation material. After three months of storage, retreatment was performed (Protaper universal rotary retreatment files, Dentsply Maillefer, Ballaigues, Switzerland). Second scan of cone beam computed tomography was taken to evaluate the residual filling material. Group comparisons were performed using one way ANOVA and Post-Hoc Tukey test HSD test (P=0.05). Results: There was no statistically significant difference between the three groups (P<.05), in the residual filling material. Conclusions: In conclusion, the results of this study indicate that the obturation material could not be removed completely in all the three groups. There was no significant difference in the retreatment efficacy between propoint and gutta-percha.

Effect of irrigants using ultrasonics on intracanal calcium hydroxide removal – an in vitro comparative evaluation

Aim: To evaluate the efficacy of various irrigating solutions on calcium hydroxide (Apex cal andRC cal) removal with the use of ultrasonics. Methods: The root canals of 120 single-rootedmaxillary central incisors were prepared using the stepback technique. The teeth were decoronatedand split longitudinally. After filling, the two halves of roots were reassembled with sticky wax andeach group was further divided into four subgroups according to the irrigating solution: SmearClear, 10% citric acid, 5% EDTA and 3% NaOCl. Evaluation for cleanliness was done under amicroscope with ×12.5 magnification. Statistical analysis was done with Kruskal Wallis and MannWhitney tests at 5% level of significance. Results: There was no statistically significant difference(p>0.05) for calcium hydroxide (Apex Cal and RC Cal) removal by different irrigants. There weremore residues in the apical groove than in the coronal groove (p<0.05). Conclusions: Whenthe different irrigants were compared at coronal and apical levels, Smear Clear and citric acidwere more effective in calcium hydroxide removal than EDTA and NaOCl.